Path to Synthesis

A negative fluoride ion, from HF, will remove the triethylsilyl group from the oxygen that was protected previously. The S_N2 reaction will leave an extra electron on the oxygen, which will then capture a hydrogen ion to reform the hydroxyl group.

This same reaction is repeated for the protected alcohol at carbon #2´ of the side chain.

Once both alcohols have been de-protected, the synthesis of taxol is completed.

		A negative fluoride ion, from HF, will remove the triethylsilyl group from the oxygen that was protected previously. The S_N2 reaction will leave an extra electron on the oxygen, which will then capture a hydrogen ion to reform the hydroxyl group. This same reaction is repeated for the protected alcohol at carbon #2´ of the side chain. Once both alcohols have been de-protected, the synthesis of taxol is completed.
		Credits &rArr

Step 10 &mdash deprotection of 2´,7-bis(triethylsilyl) taxol